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What to expect with ALYGLO™

ALYGLO is 1 infusion every 3-4 weeks administered in your own home or an infusion clinic.1

1

Your doctor prescribes ALYGLO: When your doctor diagnoses you with primary immunodeficiency (PI), you may receive a prescription for immunoglobulin (IG) replacement therapy like ALYGLO.

2

A specialty pharmacy provides the treatment: After your doctor prescribes ALYGLO, you may be referred to a specialty pharmacy that stocks and administers the treatment. A nurse from the specialty pharmacy may work directly with you to schedule the first infusion.

3

Your treatment may be administered in your own home or at an infusion clinic: ALYGLO dosing depends on body weight.1 Total infusion time depends on dose and rate of infusion.1 Some people have a shorter infusion, while others may require more time. Your healthcare team can determine your infusion schedule (every 3 or 4 weeks) depending on your clinical needs.

Treatment tip

Make sure you drink plenty of water the day before and the day of your infusion, avoiding caffeine and alcohol. Save a good book or show to help you pass the time while you receive your infusion.

Learn how we can help
cover the cost of ALYGLOa

ALYGLO co-pay assistance is available to help eligible patients address any worries about out-of-pocket expenses for ALYGLO. When you’re prescribed ALYGLO, co-pay assistance helps avoid treatment delays or lengthy approval processes.

Click here to enroll in ALYGLO co-pay assistance.

aClick here to see terms, conditions, and eligibility criteria.

Reference:

  1. ALYGLO Prescribing Information. GC Biopharma; 2023.
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INDICATION
ALYGLO™ is indicated for the treatment of primary humoral immunodeficiency (PI) in adults aged 17 years and older. This includes, but is not limited to, congenital agammaglobulinemia, common variable immunodeficiency (CVID), Wiskott-Aldrich syndrome, and severe combined immunodeficiencies.

IMPORTANT SAFETY INFORMATION
  • Thrombosis (blood clot formation) can happen with ALYGLO. Factors that increase this risk include advanced age, prolonged immobility, certain medical conditions, and cardiovascular risk factors.
  • ALYGLO may affect the kidneys. In some cases, it can lead to acute renal failure or death.
  • If you’re at risk for blood clots or kidney problems, your doctor should give you ALYGLO at the lowest effective dose and infusion rate. Staying well-hydrated before treatment is essential.
  • ALYGLO is not suitable for people who have had severe allergic reactions to immune globulin or those with IgA deficiency and a history of hypersensitivity.
  • If you experience any signs of hypersensitivity during the infusion, treatment should be stopped and epinephrine (an emergency medication) should be administered immediately.
  • ALYGLO may cause hyperproteinemia, increased serum viscosity, and hyponatremia (low sodium levels).
  • Aseptic Meningitis Syndrome (AMS) is a rare condition that can occur after receiving ALYGLO, especially with high doses or rapid infusion. Symptoms usually start within a few hours to 2 days after treatment. If AMS occurs, stopping ALYGLO usually leads to improvement within several days without lasting effects.
  • Hemolysis, a breakdown of red blood cells, may occur. Some patients may experience delayed hemolytic anemia due to increased sequestration of red blood cells. Severe hemolysis-related kidney dysfunction or disseminated intravascular coagulation has been reported.
  • Transfusion-Related Acute Lung Injury (TRALI) is a rare complication characterized by severe respiratory distress, pulmonary edema, and fever. Patients with TRALI may need oxygen therapy and ventilator support.
  • ALYGLO is made from human blood, which may carry a risk of transmitting infectious agents (such as viruses).
  • After receiving ALYGLO, some antibodies from the treatment may temporarily show up in blood tests. This could lead to misleading results, so your healthcare provider will consider this when interpreting lab results.
  • Common side effects include headache, nausea/vomiting, fatigue, nasal/sinus congestion, rash, arthralgia, diarrhea, muscle pain/aches, infusion site pain/swelling, abdominal pain/discomfort, cough, and dizziness.

For more information about ALYGLO, talk to your doctor and see the Product Information here.